KLK7 / Kallikrein 7蛋白产品信息
别名: KLK7, Prss6, Scce
表达方式:
A DNA sequence encoding the mouse KLK7 (Q91VE3) (Met1-Arg249) was expressed with a C-terminal polyhistidine tag.
种属: Mouse
表达宿主: Human Cells
KLK7 / Kallikrein 7 Protein QC Testing
纯度: >(71.4+26)% as determined by SDS-PAGE SDS-PAGE:
KLK7 / Kallikrein 7 protein
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gln 22
分子量:
The recombinant mouse KLK7 comprises 239 amino acids and has a predicted molecular mass of 26.5 kDa. The apparent molecular mass of the protein is approximately 31 and 34 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
KLK7 / Kallikrein 7 Protein Usage Guide
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
KLK7 / Kallikrein 7蛋白背景综述
Kallikrein-7, also known as kallikrein-related peptidase 7, Stratum corneum chymotryptic enzyme, Serine protease 6, KLK7, and PRSS6, is a secreted protein which belongs to the peptidase S1 family and Kallikrein subfamily. Members of the Kallikrein family are involved in various malignancies such as prostate (PSA, KLK2, KLK15), ovarian (KLK4, KLK5, KLK6, KLK8, KLK10), and breast cancer (KLK10, KLK13, KLK14). Kallikrein-7 / KLK7 appears to be increased in ovarian cancer and higher KLK7 expression in ovarian cancer tissue is associated with poorer prognosis of ovarian cancer patients. Kallikrein-7 / KLK7 is abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Kallikrein-7 / KLK7 is up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at the protein level). It was significantly associated with shorter overall survival (OS) and disease-free survival (DFS). Kallikrein-7 / KLK7 may catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. KLK7 also plays a role in the activation of precursors to inflammatory cytokines.
参考文献
Dong Y. et al., 2003, Clin Cancer Res. 9 (5): 1710-20.
Kyriakopoulou LG. et al., 2003, Clin Biochem. 36 (2): 135-43.
Talieri M. et al.,2004,Thromb Haemost. 91 (1): 180-6.
Talieri M. et al., 2009, Thromb Haemost. 101 (4): 741-7.
规格：10ug
关 键 词：Mouse KLK7 / Kallikrein 7 Protein,技术资料,参数，实验室耗材，生化试剂，上海创赛，博飞美科，实验仪器，厂家
CANSPEC品质提供的Mouse KLK7 / Kallikrein 7 Protein|技术资料|参数性能**，其优良的品质满足您不同实验的多种需求。
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