Mouse S100B / S100beta Protein|技术资料|厂家价格

S100B / S100beta蛋白产品信息

别名: S100B
表达方式: 
A DNA sequence encoding the mouse S100B (P50114)(Ser2-Glu92) was expressed with the fused Fc region of human IgG1 at the N-terminus.
种属: Mouse
表达宿主: Human Cells

S100B / S100beta Protein QC Testing

纯度: > 80 % as determined by SDS-PAGE SDS-PAGE
生物活性:
1. Measured by its binding ability in a functional ELISA.
2. Immobilized recombinant mouse S100B-Fc (Cat:50986-M01H) at 10 μg/ml (100 μl/well) can bind biotinylated recombinant human AGER (Cat:11629-HNCH) with a linear range of 0.03-0.5 ug/ml.
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu
分子量: 
The recombinant mouse S100B/Fc  comprises 351 amino acids and has a predicted molecular mass of 39 kDa. The apparent molecular mass of the protein is approximately 41 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

S100B / S100beta Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

S100B / S100beta蛋白背景综述

S100B is a member of the S100 family of proteins containing two EF-hand-type calcium-binding motifs. In humans at least 20 S100 family members that are distributed tissue specifically have been identified, and are involved in a number of cellular processes as transducers of calcium signal. Although most of the S100 genes are located as a cluster at 1q21, S100B gene is located at 21q22.3. S100B is glial-specific and is synthesized in considerable amounts in the cytoplasm of astrocytes. This protein has been revealed to preform a variety of intracellular functions including cell proliferation, cell structure, energy metabolism, and calcium homeostasis. S100B is probably implicated in tumor progression by excessive down-regulation of the p53 tumor suppressor protein. As a neurotrophic factor, S100B stimulates neurite outgrowth and enhances survival of neurons during CNS development. Chromosomal rearrangements and abberant expression of S100B gene are associated with several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.

参考文献

Allore R. et al., 1988, Science. 239: 1311-1313.
Esposito G. et al., 2008, J Cell Mol Med. 12: 914-927.
Rothermundt M. et al., 2003, Microsc Res Tech. 60: 614-632.
Lin J. et al., 2004, J Biol Chem. 279: 34071-34077.
Nishiyama H. et al., 2002, Proc Natl Acad Sci. 99: 4037-4042.

规格：50ug

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