Rat ErbB3 / HER3 Protein|价格|技术资料

ErbB3 / HER3蛋白产品信息

别名: ERBB3
表达方式: 
A DNA sequence encoding the rat ERBB3 (Q62799)(Met1-His641) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Rat
表达宿主: Human Cells

ErbB3 / HER3 Protein QC Testing

纯度: > 80% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Ser 20
分子量: 
The recombinant rat ERBB3/Fc is a disulfide-linked homodimer. The reduced monomer comprises 863 amino acids and has a predicted molecular mass of 95.5 kDa. The apparent molecular mass of the protein is approximately 115 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

ErbB3 / HER3 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

ErbB3 / HER3蛋白背景综述

ErbB3, also known as Her3 (human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.

参考文献

Kraus MH. et al., 1989, Proc Natl Acad Sci. 86: 9193-7.
Carraway K.L. et al., 1994, J Biol Chem. 269: 14303-6.
Wallasch C. et al., 1995, EMBO J. 14: 4267-75.
Alimandi M. et al., 1995, Oncogene. 10: 1813-21.
Gamett DC. et al., 1995, J Biol Chem. 270: 19022-7.
Katoh M. et al., 1993, Biochem Biophys Res Commun.192: 1189-97.

规格：50ug

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