Rat CD34 Protein|鼠CD34蛋白|参数|价格

CD34蛋白产品信息

别名: CD34
表达方式: 
A DNA sequence encoding the rat CD34 (B1PLB1)(Met1-Thr291) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Rat
表达宿主: Human Cells

CD34 Protein QC Testing

纯度: > 80% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu 37
分子量: 
The recombinant rat CD34/Fc is a disulfide-linked homodimer. The reduced monomer comprises 496 amino acids and has a predicted molecular mass of 54.5 kDa. The apparent molecular mass of the protein is approximately 112 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CD34 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CD34蛋白背景综述

CD34 molecule is a member of a family of single-pass transmembrane sialomucin proteins, and is selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. As a monomeric cell surface antigen, CD34 is highly glycosylated with nine potential N-linked and numerous potential O-linked glycosylation sites in its extracellular domain. Although used clinically in hematopoietic stem cell transplantation for more than 15 years, little is known about the exact function of CD34. It may act as an adhesion molecule in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells, and is also required for T cells to enter lymph nodes via interaction with L-selectin. It was indicated that CD34 is a phosphorylation target for activated PKC, and couples to the hematopoietic adapter protein CrkL, which were involved in CD34 signaling pathways. CD34 is abberantly expressed in many kinds of tumors and is implicated in leukemogenesis.

参考文献

Fackler MJ. et al., 1990, J Biol Chem. 265: 11056-61.
Simmons DL. et al., 1992, J Immunol. 148: 267-71.
Latailade JJ. et al., 2000, Blood. 95: 756-68.
Furness SG. et al., 2006, Immunol Res. 34: 13-32.

规格：20ug

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