Rat CD24 / Ly-52 / CD24A Protein|厂家|使用说明|参数

CD24 / Ly-52 / CD24A蛋白产品信息

别名: CD24, Cd24a
表达方式: 
A DNA sequence encoding the rat CD24 (Q07490 )(Met1-Cys55) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Rat
表达宿主: Human Cells

CD24 / Ly-52 / CD24A Protein QC Testing

纯度: > 90% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Asn 27
分子量: 
The recombinant rat CD24/Fc is a disulfide-linked homodimer. The reduced monomer comprises 270 amino acids and has a predicted molecular mass of 29.9 kDa. The apparent molecular mass of the protein is approximately 43-48 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CD24 / Ly-52 / CD24A Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CD24 / Ly-52 / CD24A蛋白背景综述

Signal transducer CD24, also known as small cell lung carcinoma cluster 4 antigen, CD24 and CD24A, is a cell membrane protein which belongs to the CD24 family. It is expressed in a number of B-cell lines including P32/SH and Namalwa. It is also expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells. CD24 modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. CD24 promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. Genetic variations in CD24 are associated with susceptibility to multiple sclerosis (MS). A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens. CD24 may act as a genetic modifier for susceptibility and progression of multiple sclerosis (MS) in some populations, perhaps by affecting the efficiency of CD24 expression on the cell surface.

参考文献

Jackson D. et al., 1992, Cancer Res. 52: 5264-70.
Hough MR. et al., 1994, Genomics. 22: 154-61.
Zarn JA. et al., 1996, Biochem Biophys Res Commun. 225: 384-91.
Suzuki T. et al., 2001, J Immunol. 166: 5567-77.
Zhou Q. et al., 2003, Proc. Natl. Acad. Sci. 100: 15041-6.

规格：50ug

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