Rat BST-1 / BST1 Protein|产品详情|厂家现货

BST-1 / BST1蛋白产品信息

别名: BST1
表达方式: 
A DNA sequence encoding the rat BST1 (Q63072)(Met1-Glu293) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Rat
表达宿主: Human Cells

BST-1 / BST1 Protein QC Testing

纯度: > 95% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Ala 28
分子量: 
The recombinant rat BST1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 506 amino acids and has a predicted molecular mass of 56.8 kDa. The apparent molecular mass of the protein is approximately 67 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

BST-1 / BST1 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

BST-1 / BST1蛋白背景综述

CD157, also known as bone marrow sromal cell antigen 1 (BST-1), is a glycosylphosphatidylinositol-anchored ectoenzyme belonging to the NADase/ADP-ribosyl cyclase family. It is expressed in the bone marrow, spleen and thymus in lymphoid organs, and the lung, kidney and heart in non-lymphoid organs. In mouse, CD157 is also expressed on lymphoid progenitors. It has a dual nature behaving both as an ectoenzyme and as a receptor. Cross-linking of CD157 induces intracellular Ca2+ mobilization and re-shaping in neutrophils, thus regulating their adhesive and migratory properties. The CD157-mediated signals promote cell polarization, regulate chemotaxis induced through the high affinity formyl-methionyl-leucyl-phenylalanine (fMLP) receptor and control transendothelial migration. CD157 exhibits homology with CD38 and Aplysia ADP-ribosyl cyclase. Like CD38, it has both ADP-ribosyl cyclase and cADPR hydrolase activities. The CD157 gene is synthenic on 4p15 with CD38, with which it also shares a unique genomic organization. Their conservation in phylogeny is striking evidence for their relevance in the life and death cycle of the cell. CD157 has a specific and crucial role in the regulation of innate immunity during inflammation. The murine CD157 is a useful marker for lymphoid progenitor cells initiating gene rearrangement of their antigen receptors.

参考文献

Muraoka O. et al., 1996, Immunol Lett. 54 (1): 1-4.
Ishihara K. et al., 1996, Int Immunol. 8 (9): 1395-404.
Kajimoto Y. et al., 1996, Biochem Biophys Res Commun. 219 (3): 941-6.
Ortolan E. et al., 2002, Cell Biochem Funct. 20(4): 309-22.
Funaro A. et al., 2004, Blood. 104 (13): 4269-78.
Lavagno L. et al., 2007, J Biol Regul Homeost Agents. 21 (1-2): 5-11.
Funaro A. et al., 2009, Front Biosci. 14: 929-43.

规格：50ug

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