Rat JAM-2 / JAM-B Protein|技术资料|价格

JAM-2 / JAM-B蛋白产品信息

别名: JAM2
表达方式: 
A DNA sequence encoding the rat JAM2 (Q3MHC0)(Met1-Asn236) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Rat
表达宿主: Human Cells

JAM-2 / JAM-B Protein QC Testing

纯度: > 90% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Phe 29
分子量: The recombinant rat JAM2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 449 amino acids and has a predicted molecular mass of 50.3 kDa. The apparent molecular mass of the protein is approximately 61 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

JAM-2 / JAM-B Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

JAM-2 / JAM-B蛋白背景综述

Junctional adhesion molecule B, also known as Junctional adhesion molecule 2, Vascular endothelial junction-associated molecule, CD322 and JAM2, is a single-pass type I  membrane protein which belongs to the immunoglobulin superfamily. JAM2 contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. JAM2 is prominently expressed on high endothelial venules. It is also present on the endothelia of other vessels. JAM2 is Localized to the intercellular boundaries of high endothelial cells. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. JAM2 is localized in the tight junctions between high endothelial cells. JAM2 acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs. Mouse JAM2 may play a role in the processes of lymphocyte homing to secondary lymphoid organs.

参考文献

Cunningham SA. et al., 2000, J Biol Chem. 275: 34750-6.
Gardiner K. et al., 2002,Genomics. 79: 833-43.
Ota T. et al., 2004, Nat Genet. 36 :40-5.
Zhang Z. et al., 2004, Protein Sci. 13: 2819-24.

规格：50ug

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