Cynomolgus CXCL7 / NAP-2 / PPBP Protein|价格|参数

CXCL7 / NAP-2 / PPBP蛋白产品信息

别名: PPBP
表达方式: 
A DNA sequence encoding the cynomolgus PPBP(F6SCP6) (Thr59-Asp128) was expressed fused with the Fc region of mouse IgG1 at the N-terminus.
种属: Cynomolgus
表达宿主: Human Cells

CXCL7 / NAP-2 / PPBP Protein QC Testing

纯度: > 90 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Asp
分子量: 
The recombinant cynomolgus PPBP is a disulfide-linked homodimer. The reduced monomer comprises 306 amino acids and has a calculated molecular mass of 34.3 KDa.The apparent molecular mass of it is approximately 38 KDa respectively in SDS-PAGE.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CXCL7 / NAP-2 / PPBP Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CXCL7 / NAP-2 / PPBP蛋白背景综述

Pro-platelet basic protein (PPBP) is also known as Chemokine (C-X-C motif) ligand 7 (CXCL7) and nucleosome assembly protein (Nap-2). This protein is a platelet-derived growth factor that belongs to the CXC chemokine family. CXCL7 / NAP-2 / PPBP / CXCL7 is released in large amounts from platelets following their activation. This growth factor is a potent chemoattractant and activator of neutrophils. CXCL7 / NAP-2 / PPBP / CXCL7 has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. Nap-2 is a ligand for CXCR1 and CXCR2, and Nap-2, Nap-2(73), Nap-2 (74), Nap-2(1-66), and most potent Nap-2(1-63) are chemoattractants and activators for neutrophils.

参考文献

Walz A. et al., 1989, J Exp Med. 170 (5): 1745-50.
Walz A. et al., 1990, J Exp Med. 171 (2): 449-54.
Loetscher P. et al., 1994, FEBS Lett. 341 (2-3): 187-92.

规格：10ug

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