B3GNT2 Protein|B3GNT2蛋白质|价格|技术资料

B3GNT2蛋白产品信息

别名: B3GNT2, B3GALT7, B3GNT1
表达方式: 
A DNA sequence encoding the human B3GNT2 (Q9NY97-1)(Lys29-Cys397) was expressed ,with the fused Fc region of human IgG1 at the N-terminus.
种属: Human
表达宿主: Human Cells

B3GNT2 Protein QC Testing

纯度: > 90 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu
分子量: 
The recombinant human B3GNT2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 629 amino acids and has a predicted molecular mass of 71.2 kDa. The apparent molecular mass of the protein is approximately 112-120 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

B3GNT2 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

B3GNT2蛋白背景综述

B3GNT2 is a member of the beta-1,3-N-acetylglucosaminyltransferase family. As a type II transmembrane protein, it prefers the substrate of lacto-N-neotetraose. Alternative splicing produced 2 isoforms of the human protein. Enzymatic activities of some glycosyltransferases are markedly increased via complex formation with other transferases or cofactor proteins. B3GNT2 catalyzes the initiation and elongation of poly-N- acetyllactosamine chains. B3GNT2 and beta3Gn-T8 can form a heterodimer in vitro and that the complex exhibits much higher enzymatic activity than either enzyme alone. It is found that up-regulation of beta3Gn-T8 in differentiated HL-60 cells may increases poly-N-acetyllactosamine chains by activating intrinsic B3GNT2.

参考文献

Australo-Anvc .et al., 2010, Nat Genet. 42 (2): 123-7.
Kim W. et al., 2011, Mol Cell. 44 (2): 325-40.
Seko A. et al., 2008, J Biol Chem. 283 (48): 33094-100.

规格：20ug

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