MFAP5 / MAGP2 Protein|产品详情|参数

MFAP5 / MAGP2蛋白产品信息

别名: MFAP5
表达方式: 
A DNA sequence encoding the human MFAP5 (Q13361) (Met1-Leu173) with a C-terminal polyhistidine tag was expressed.
种属: Human
表达宿主: Human Cells

MFAP5 / MAGP2 Protein QC Testing

纯度: >(54.7+31.5)% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Arg 22
分子量: 
The recombinant human MFAP5 comprises 163 amino acids and has a predicted molecular mass of 18.7 kDa. The apparent molecular mass of the protein is approximately 54 and 29 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile  PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

MFAP5 / MAGP2 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.


MFAP5 / MAGP2蛋白背景综述

MFAP5, also called MAGP2, is a secreted, cell-associated 25 kDa mammalian member of the MFAP family of proteins. MFAP5 is rich in serine and threonine residues. It also has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils. As a 25-kD microfibril-associated glycoprotein, MFAP5 stimulates the assembly of elastic fibers, a complex structure composed of a tropoelastin inner core and microfibril outer mantle comprising proteins such as fibrillins and microfibril-associated glycoproteins that guide tropoelastin deposition. MFAP5 can function also outside of its role in elastic fibers and activates cellular signaling pathways. It interacts with the EGF-like repeats of Notch-1, which leads to both cell surface release of the Notch-1 extracellular domain and subsequent activation of Notch signaling.

参考文献

Hatzinikolas G. et al., 1998, J Biol Chem. 273 (45): 29309-14.
Gibson MA. et al., 1996, J Biol Chem. 271 (2): 1096-103.
Miyamoto A. et al., 2006, J Biol Chem. 281 (15):10089-97.

规格：50ug

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