Mouse PGRL / IGSF8 Protein |技术资料|参数

PGRL / IGSF8蛋白产品信息

别名: IGSF8, Ewi2, Kct4, Pgrl
表达方式: 
A DNA sequence encoding the mouse IGSF8 (AAH48387.1) (Met1-Thr577) was expressed with a C-terminal polyhistidine tag.
种属: Mouse
表达宿主: Human Cells

PGRL / IGSF8 Protein QC Testing

纯度: > 95% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Arg 26
分子量: 
The recombinant mouse IGSF8 comprises 563 amino acids and has a predicted molecular mass of 60.2 kDa. The apparent molecular mass of the protein is approximately 66 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

PGRL / IGSF8 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

PGRL / IGSF8蛋白背景综述

Immunoglobulin superfamily member 8, also known as IGSF8, PGRL, and CD316, is a single-pass membrane protein with a short cytoplasmic domain interacting with membrane PIPs and mediating plasma membrane localization. It is expressed in brain, kidney, testic, liver and placenta with moderate expression in all other tissues. This protein has been detected on a majority of B-cells, T-cells, and nature killer cells but not on monocytes, polynuclear cells and platelets. IGSF8 may play a role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. It also regulate proliferation and differentiation of keratinocytes. IGSF8 may be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. It may also play a role on integrin-dependent morphology and motility functions and participate in the regulation of neurite outgrowth and maintenance of the neural network in the ***** brain.

参考文献

Glazar AI. et al., 2009, Reprod Fertil Dev. 21 (2): 293-303.
Murdoch JN. et al., 2003, Mol Cell Neurosci. 22 (1): 62-74.
Zhang XA. et al., 2003, Cancer Res. 63 (10): 2665-74.

规格：20ug

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