Rat TGFBR2 / TGF beta-2 / TGFB2 Protein|厂家|产品详情

TGFBR2 / TGF-beta-2 / TGFB2蛋白产品信息

别名: TGFBR2
表达方式: 
A DNA sequence encoding the rat TGFBR2 (P38438) (Met1-Gln166) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Rat
表达宿主: Human Cells

TGFBR2 / TGF-beta-2 / TGFB2 Protein QC Testing

纯度: > 95% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Ile 24
分子量: 
The recombinant rat TGFBR2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 384 amino acids and has a predicted molecular mass of 43 kDa. The apparent molecular mass of the protein is approximately 54 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

TGFBR2 / TGF-beta-2 / TGFB2 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

TGFBR2 / TGF-beta-2 / TGFB2蛋白背景综述

Transforming growth factor beta 2 (TGF beta 2), a member of the TGF-beta family, is a secreted protein known as a cytokine that performs many cellular functions. TGF beta 2 has a vital role during embryonic development. In the early avian embryo TGF beta 2 has a major role in the retinoic acid-regulated posterior heart morphogenesis for which it does not use Smad2/3 pathways, but may use other signaling pathways. TGF beta 2 induces senescence-associated trabecular meshwork (TM) changes and activates the senescence-related p16-pRb signal transduction pathway in vitro. Thus, minimizing TGF beta 2 levels may help to prevent the ageing process in the TM as seen in primary open angle glaucoma (POAG). TGF beta 2 suppresses proliferation of epithelial cells and stimulates synthesis of certain caspases. Then TGF beta 2 triggers the intrinsic caspase network and subsequently epithelial cells are eliminated through apoptotic cell death. The increased levels of TGF beta 2 triggered a neuronal cell death pathway related to Alzheimer's disease (AD) by binding to the extracellular domain of amyloid beta precursor protein (APP). The upregulation of the TGF beta 2 level is a common pathological feature of AD brains and suggests that it may be closely linked to the development of neuronal death related to AD. TGF-beta regulates key mechanisms of tumor development, namely immunosuppression, metastasis, angiogenesis, and proliferation. TGF beta 2 suppression is a promising therapeutic approach for malignant tumor therapy.

参考文献

Ghatpande SK. et al., 2010, Dev Growth Differ. 52 (5): 433-55.
Yu AL. et al., 2010, Invest Ophthalmol Vis Sci. 51 (11): 5718-23.
Hibino T. et al., 2004, J Dermatol Sci. 35 (1): 9-18.
Noguchi A. et al., 2010, Int J Neurosci. 120 (3): 168-75.
Schlingensiepen KH. et al., 2006, Cytokine Growth Factor Rev. 17 (1-2): 129-39.

规格：50ug

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