Rat IL20RB Protein|鼠IL20RB蛋白质|参数|价格

IL20RB蛋白产品信息

别名: IL20RB
表达方式: 
A DNA sequence encoding the rat IL20RB (B8K1X9) (Met1-Pro227) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Rat
表达宿主: Human Cells

IL20RB Protein QC Testing

纯度: > 70% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Phe 22
分子量: 
The recombinant rat IL20RB/Fc is a disulfide-linked homodimer. The reduced monomer comprises 447 amino acids and has a predicted molecular mass of 50.2 kDa. The apparent molecular mass of the protein is approximately 61 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

IL20RB Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IL20RB蛋白背景综述

IL20RB contains 2 fibronectin type-III domains and belongs to the type II cytokine receptor family. There are two kinds of type II cytokine receptors : cytokine receptors that bind type I and type II interferons; cytokine receptors that bind members of the interleukin-10 family (interleukin-10, interleukin-20 and interleukin-22). Type II cytokine receptors are heterodimers or multimers with a high and a low affinity component. These receptors are related predominantly by sequence similarities in their extracellular portions that are composed of tandem Ig-like domains. The intracellular domain of type II cytokine receptors is typically associated with a tyrosine kinase belonging to the Janus kinase (JAK) family. IL20RB is widely expressed with highest levels in skin and testis and highly expressed in psoriatic skin. The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24.

参考文献

Zhu H. et al., 2009, Hepatobiliary Pancreat Dis Int. 8 (4): 402-6.
Logsdon NJ. et al., 2012, Acta Crystallogr Sect F Struct Biol Cryst Commun. 68 (1): 89-92.
Kingo K. et al., 2008, Genes Immun. 9 (5): 445-51.

规格：50ug

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