Rat DDR2 Kinase / CD167b Protein|厂家|技术资料

DDR2蛋白产品信息

别名: DDR2
表达方式: 
A DNA sequence encoding the rat DDR2 (B1WC09)(Met1-Arg399) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Rat
表达宿主: Human Cells

DDR2 Protein QC Testing

纯度: > 80% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gln 24
分子量: The recombinant rat DDR2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 617 amino acids and has a predicted molecular mass of 69.5 kDa. The apparent molecular mass of the protein is approximately 110 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

DDR2 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

DDR2蛋白背景综述

Discoidin domain receptor 2 (DDR2), also known as TYR010 and TKT, is a type I  transmembrane glycoprotein and belongs to discoidin-like domain containing subfamily of receptor tyrosine kinases (RTKs). All family members share the discoidin (DS) homology domain, a long juxtamembrane domain, a transmembrane region, and a tyrosine kinase domain. DDR2 is mainly expressed in mesenchymal cells and is unique among RTKs in that its ligand is fibrillar collagen rather than a growth factor-like peptide. Ligand binding induces DDR2 autophosphorylation in the cytoplasmic domain and the adaptor proteins SHC have been identified as key signaling mediators in DDR2 signal transduction. Activation of DDR2 by collagen induces upregulation of MMP-1, -2, and -13 as well as DDR2 itself. It has been suggested that DDR2 plays an important role in mediating chondrocyte, hepatic stellate cells and fibroblast migration and proliferation by MMP2–dependent mechanism. Accordingly, aberrant expression of DDR2 is implicated in tumor growth and invasion.

参考文献

Voqel W. et al., 1997, Mol Cell. 1: 13-23.
Alves F. et al., 1995, Oncogene. 10: 609-18.
Leitinqer B. et al., 2006. Matrix Biol. 25: 355-64.
Wall SJ. et al., 2005, J. Biol. Chem. 48: 40187-94.
Ferri N. et al., 2004, Am J Pathol. 164: 1575–85.
Ikeda K. et al., 2002, J Biol Chem. 277: 19206-12.

规格：50ug

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