Rat CD5 Protein|鼠CD5蛋白质|参数|价格

CD5蛋白产品信息

别名: CD5
表达方式: 
A DNA sequence encoding the rat CD5 (P51882) (Met1-Pro368) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Rat
表达宿主: Human Cells

CD5 Protein QC Testing

纯度: > 95% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gly 24
分子量: 
The recombinant rat CD5/Fc is a disulfide-linked homodimer. The reduced monomer comprises 586 amino acids and has a predicted molecular mass of 64.5 kDa. The apparent molecular mass of the protein is approximately 85 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

    
CD5 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CD5蛋白背景综述

T-cell surface glycoprotein CD5, also known as Lymphocyte antigen T1 and LEU1, is a single-pass type I  membrane protein. CD5 contains 3 SRCR domains and has been regarded as a possible B cell lineage marker differentiating subsets, CD5+ B cells (also termed B1 cells) and conventional B cells (or B2 cells). CD5 is expressed at various developmental and activation stages on human B cells. It is a well established negative regulator of TCR and BCR signalling. Increased expression of CD5 on either T cells or B cells protects against autoimmunity. CD5-positive cells may also prevent the emergence of autoimmunity by provision of cytokines such as IL-10. The physiological role of CD5 might be to control the generation of aberrant immune responses. In cancers, CD5 expression plays a role in the fate of tumour-specific T cells, rendering lymphocytes tolerant and unable to recognize and eliminate malignant cells. Development, selection and function of different B- and T-cell subsets or their preferential survival may be directly or indirectly dependent on different glycan structures associated with CD5 or CD5-like molecules.

参考文献

Heuring AH. et al., 2001, The British journal of ophthalmology. 85 (4): 498-9.
Dalloul A. 2009, Autoimmun Rev. 8 (4): 349-53.
Pospisil R. et al., 2009, Mol Immunol. 46 (13): 2456-64.

规格：50ug

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