Cynomolgus ACVR1B / ALK-4 Protein|技术资料|价格

ACVR1B / ALK-4蛋白产品信息

别名: ACVR1B
表达方式: 
A DNA sequence encoding the cynomolgus ACVR1B(F7HNS7) (Met1-Glu126) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Cynomolgus
表达宿主: Human Cells

ACVR1B / ALK-4 Protein QC Testing

纯度: > 85 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Arg 27
分子量: 
The recombinant cynomolgus ACVR1B is a disulfide-linked homodimer. The reduced monomer comprises 341 amino acids and has a calculated molecular mass of 38.2 KDa.The apparent molecular mass of it is approximately 44 KDa respectively in SDS-PAGE.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

ACVR1B / ALK-4 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

ACVR1B / ALK-4蛋白背景综述

Activin receptor type-IB, also known as Serine/threonine-protein kinase receptor R2, Activin receptor-like kinase 4, ALK-4, and ACVRIB, is a single-pass type I  membrane protein which belongs to the protein kinase superfamily and TGFB receptor subfamily. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I  (I and IB) and two type I I (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. ALK-4 is expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver. ALK4 and ALK7 can mediate signal transduction by Nodal proteins, although ALK7 appears to be a receptor more specifically dedicated to Nodal signaling.

参考文献

Reissmann E. et al., 2001, Genes Dev. 15 (15): 2010-22.
Su GH. et al., 2001, Proc Natl Acad Sci . 98 (6): 3254-7.
Inman GJ. et al., 2002, Mol. Pharmacol. 62 (1): 65-74.
Harrison CA. et al., 2003, J. Biol. Chem. 278 (23): 21129-35.

规格：50ug

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