TMED1 Protein|TMED1蛋白质|参数|实验说明

TMED1蛋白产品信息

别名: TMED1, IL1RL1L, IL1RL1LG
表达方式: 
A DNA sequence encoding the human TMED1 (Q13445) (Met1-Asn194) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Human
表达宿主: Human Cells

TMED1 Protein QC Testing

纯度: > 90 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Ala 24
分子量: 
The recombinant human TMED1 /Fc is a disulfide-linked homodimer. The reduced monomer comprises 412 amino acids and has a predicted molecular mass of 46.2 kDa. The apparent molecular mass of the protein is approximately 57 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

TMED1 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

TMED1蛋白背景综述

TMED1 is a member of the EMP24/GP25L family. It is widely expressed and contains 1 GOLD domain. TMED1 may play a role in vesicular protein trafficking, mainly in the early secretory pathway. It may act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. TMED1 binds to its receptor IL1RL1 and results in the activation of DNA binding by nuclear factor NF-kappa-B or transcription from the IL8 promoter and most likely requires other proteins to elicit these activities. Dendritic cells from Peyer's patches (but not from spleen) express TMED1 in response to treatment with LPS.

参考文献

Colland F. et al., 2004, Genome Res. 14 (7): 1324-32.
Gerhard DS. et al., 2005, Nature. 437 (7062): 1173-8.
Gerhard DS. et al., 2004, Genome Res. 14 (10B): 2121-7.

规格：20ug

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