PIK3IP1 Protein|PIK3IP1蛋白质|价格|产品详情

PIK3IP1蛋白产品信息

别名: PIK3IP1, HGFL
表达方式: 
A DNA sequence encoding the human PIK3IP1 (AAH11049.1)(Met1-Thr168) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Human
表达宿主: Human Cells

PIK3IP1 Protein QC Testing

纯度: > 85 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Ser 22
分子量: 
The recombinant human PIK3IP1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 388 amino acids and has a predicted molecular mass of 42.7 kDa. The apparent molecular mass of the protein is approximately 55 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

PIK3IP1 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

PIK3IP1蛋白背景综述

PIK3IP1 contains 1 kringle domain and is a negative regulator of phosphatidylinositol-3-kinase (PI3K), suppresses the development of hepatocellular carcinoma. In most cell types, PI3K functions as a regulator of cell division, motility, metabolism and survival in. Proper liver function and development highly depend on intact PI3K signal transduction. Aberrant PI3K pathway signaling in the liver  can cause hepatocellular carcinoma. PI3K signaling is involved in the homeostasis of lipid and glucose metabolism. Activation of the PI3K pathway induces lipogenesis and glycogenesis in the liver, since both Akt overexpressing transgenic mice and PTEN knockout mice develop fatty liver and hypoglycemia. PIK3IP1 overexpression can contribute to glucose homeostasis and fatty deposition.

参考文献

He X. et al., 2008, Cancer Res. 68 (14): 5591-8.
Gao P. et al., 2008, Beijing Da Xue Xue Bao. 40 (6): 572-7.
Zhu Z. et al., 2007, Biochem Biophys Res Commun. 358 (1): 66-72.

规格：50ug

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