CANX / Calnexin Protein |CANX / Calnexin蛋白质|参数|价格

CANX / Calnexin蛋白产品信息

别名: CANX
表达方式: 
A DNA sequence encoding the human CANX (P27824)(Met1-Pro481) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Human
表达宿主: Human Cells

CANX / Calnexin Protein QC Testing

纯度: > 85 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: His 21
分子量: 
The recombinant human CANX/Fc is a disulfide-linked homodimer. The reduced monomer comprises 702 amino acids and has a predicted molecular mass of 79.4 kDa. The apparent molecular mass of the protein is approximately 110 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CANX / Calnexin Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CANX / Calnexin蛋白背景综述

Calnexin belongs to the calreticulin family. It is a calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. It seems that calnexin affects the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally calnexin may play a role in receptor-mediated endocytosis at the synapse.

参考文献

Rajagopalan S. et al., 1994, Science. 263 (5145): 387-90.
Lenter M. et al., 1994, J Biol Chem. 269 (16): 12263-8.
Pind S. et al., 1994, Science. 263 (5145): 387-90.

规格：50ug

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