MSLN / Mesothelin (aa 296-580) Protein|报价|参数

MSLN / Mesothelin蛋白产品信息

别名: MSLN, MPF
表达方式: 
A DNA sequence encoding the human MSLN (Q13421-2) (Glu296-Gly580) was expressed ,with the fused Fc region of human IgG1 at the N-terminus.
种属: Human
表达宿主: Human Cells

MSLN / Mesothelin Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu
分子量: 
The recombinant human MSLN/Fc is a disulfide-linked homodimer. The reduced monomer comprises 545 amino acids and has a predicted molecular mass of 60.7 kDa. The apparent molecular mass of the protein is approximately 65 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

MSLN / Mesothelin Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

MSLN / Mesothelin蛋白背景综述

Megakaryocyte potentiating factor is a member of the mesothelin family. This family consists of several mammalian pre-pro-megakaryocyte potentiating factor precursor (MPF) or mesothelin proteins. Both megakaryocyte potentiating factor and the cleaved form of mesothelin are N-glycosylated. Mesothelin is a tumour differentiation antigen that is normally present on the mesothelial cells lining the pleura, peritoneum and pericardium. Megakaryocyte potentiating factor is secreted by several mesothelioma cell lines and is frequently elevated in the blood of patients with mesothelioma. Measurement of this protein may be useful in following the response of mesothelioma to treatment. Megakaryocyte potentiating factor interacts with MUC16 and potentiates megakaryocyte colony formation in vitro. Its membrane-anchored forms may play a role in cellular adhesion.

参考文献

Chang MC. et al., 2012, Biochem J. 442 (2): 293-302.
Nelson HH. et al., 2011, Epigenetics. 6 (8): 1029-34.
Bournet B. et al., 2012, Pancreatology. 12 (1): 27-34.

规格：50ug

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