Mouse SHP2 / PTPN11 Protein|产品详情|现货

SHP2 / PTPN11蛋白产品信息

别名: PTPN11
表达方式: 
A DNA sequence encoding the mouse PTPN11 (P35235-2) (Met1-Arg593) was expressed with a C-terminal polyhistidine tag.
种属: Mouse
表达宿主: Human Cells

SHP2 / PTPN11 Protein QC Testing

纯度: > 90% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Met
分子量: 
The recombinant mouse PTPN11 comprises 604 amino acids and has a predicted molecular mass of 69.5 kDa. The apparent molecular mass of the protein is approximately 65 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

SHP2 / PTPN11 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

SHP2 / PTPN11蛋白背景综述

SHP2, also known as PTPN11, is a member of the protein-tyrosine phosphatase(PTP) family, non-receptor class 2 subfamily. PTPs catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. SHP2 is widely expressed, with highest levels in heart, brain, and skeletal muscle. It contains 2 SH2 domains and 1 tyrosine-protein phosphatase domain. SHP2 acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. It also dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.

参考文献

Ganju R K et al., 2000, J Biol Chem. 275 (23): 17263-8.
Yin T et al., 1997, J Biol Chem. 272 (2): 1032-7.
Kontaridis MI et al., 2006, J Biol Chem. 281 (10): 6785-92.

规格：100ug

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