Mouse NXPH1 / Neurexophilin-1 Protein|技术资料|现货

NXPH1 / Neurexophilin-1蛋白产品信息

别名: NXPH1, Nph1
表达方式: 
A DNA sequence encoding the mouse NXPH1 (Q61200) (Ala22-Gly271) was expressed with a C-terminal polyhistidine tag.
种属: Mouse
表达宿主: Human Cells

NXPH1 / Neurexophilin-1 Protein QC Testing

纯度: > 85% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Ala 22
分子量: 
The recombinant mouse NXPH1 comprises 261 amino acids and has a predicted molecular mass of 30.1 kDa. The apparent molecular mass of the protein is approximately 46-48 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

NXPH1 / Neurexophilin-1 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

NXPH1 / Neurexophilin-1蛋白背景综述

Neurexophilin-1 ( NXPH1 ) is a member of the neurexophilin family, this secreted protein with a variable N-terminal domain, a highly conserved, N-glycosylated central domain, a short linker region, and a cysteine-rich C-terminal domain. Neurexophilin-1 protein is encoded by the NXPH1 gene, which has highest level in brain. It was discovered as a neuronal glycoprotein that is copurified with neurexin Ialpha during affinity chromatography on immobilized alpha-latrotoxin. Neurexophilins represent a family of extracellular signaling molecules that interact with multiple receptors including all three alpha-neurexins. The mammalian brains contain four genes for neurexophilins the products of which share a common structure composed of five domains. Neurexophilins 1 and 3 but not 4 bind to a single individual LNS domain, the second overall LNS domain in all three alpha-neurexins. Neurexophilin-1 may be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells. As a secreted cysteine-rich glycoprotein, Neurexophilin-1 is synthesized in a subclass of neurons, and may be signaling molecules that resemble neuropeptides.

参考文献

Petrenko AG. et al., 1996, J Neurosci. 16(14): 4360-9.
Missler M. et al., 1998, J Biol Chem. 273(52): 34716-23.
Missler M. et al., 1998, J Neurosci. 18(10): 3630-8.

规格：50ug

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