Mouse BAMBI / NMA Protein|参数|价格|技术资料

BAMBI / NMA蛋白产品信息

别名: BAMBI, Nma
表达方式: 
A DNA sequence encoding the mouse BAMBI (Q9D0L6)(Met1-Ala152) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Mouse
表达宿主: Human Cells

BAMBI / NMA Protein QC Testing

纯度: > 90% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu 27
分子量: 
The recombinant mouse BAMBI /Fc is a disulfide-linked homodimer. The reduced monomer comprises 367 amino acids and has a predicted molecular mass of 41 kDa. The apparent molecular mass of the protein is approximately 45 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

BAMBI / NMA Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

BAMBI / NMA蛋白背景综述

BMP and activin membrane-bound inhibitor (BAMBI) is a transmembrane glycoprotein that is a pseudoreceptor of type 1 receptors. BAMBI structurally lacks intracellular serine/threonine kinase domain but with an extracellular domain and a short cytoplasmic region that share sequence similarities with type 1 receptors, whose members have functions in signal transduction in various developing and pathological processes. BAMBI competes with the type 1 receptor, a receptor of the transforming growth factor- beta(TGF- beta) , through functioning as negative regulators of TGF-beta by limiting the signaling range of the TGF-beta family during early embryogenesis. The expression of BAMBI can be induced by accumulated beta- catenin and BMP. The expression level of BAMBI was found aberrantly elevated in most colorectal and hepatocellular carcinomas relative to the corresponding non-cancerous tissues. It suggestes that beta-catenin and TGF-beta interfere growth arrest by inducing the expression of BAMBI, and this may contribute to colorectal and hepatocellular tumorigenesis.

参考文献

Sekiya T. et al. 2003, The Journal of Biological Chemistry. 279: 6840-6.
Shi YG. et al. 2003, Cell. 113 (6): 685-700.
Wanninger J. et al. 2011, FEBS Lett. 585 (9): 1338-44.

规格：20ug

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