CDCP1 / CD318 Protein|CDCP1 / CD318蛋白质|产品详情|价格

CDCP1 / CD318蛋白产品信息

别名: CDCP1, TRASK
表达方式: 
A DNA sequence encoding the human CDCP1 (Q9H5V8-3) (Met1-Glu343) was  fused with Fc region of mouse IgG at the C-terminus.
种属: Human
表达宿主: Human Cells

CDCP1 / CD318 Protein QC Testing

纯度: (77.1+20.1) % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Phe 30
分子量: 
The recombinant human CDCP1 /mFc is a disulfide-linked homodimer. The reduced monomer comprises 548 amino acids and has a predicted molecular mass of 61.4 kDa. The apparent molecular mass of the protein is approximately 89-93 in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CDCP1 / CD318 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CDCP1 / CD318蛋白背景综述

CDCP1 is a transmembrane protein containing three extracellular CUB domains. This protein is found to be overexpressed in colon and lung cancers. Its expression level is correlated with the metastatic ability of carcinoma cells. This protein is located on the cell surface. It has been shown to be tyrosine phosphorylated in a cancer cell line. CDCP1 is a key regulator of EGF/EGFR-induced cell migration. It may be a rational approach to inhibit progression of cancers driven by EGFR signaling including those resistant to anti-EGFR drugs because of activating mutations in the RAS/RAF/MEK/ERK pathway. It may be involved in cell adhesion and cell matrix association. It also may play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. It has been taken as a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets.

参考文献

Conze T. et al., 2003, Ann N Y Acad Sci. 996 (1): 222-6.
Hooper JD. et al., 2003, Oncogene. 22 (12): 1783-94.
Scherl-Mostageer M. et al., 2001, Oncogene. 20 (32): 4402-8.

规格：20ug

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