Rat CD70 Protein|产品详情|价格

CD70蛋白产品信息

别名: CD70
表达方式: 
A DNA sequence encoding the rat CD70 (NP_001100348) (Gln46-Pro195) was expressed, fused with a polyhistidine tag at the N-terminus.
种属: Rat
表达宿主: Human Cells

CD70 Protein QC Testing

纯度: > 90 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: His
分子量: 
The recombinant rat CD70 comprises 170 amino acids and has a predicted molecular mass of 18.9 kDa. The apparent molecular mass of the protein is approximately 28 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CD70 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CD70蛋白背景综述

CD70, also known as CD27 ligand (CD70 / CD27L / TNFSF7), is a member of the tumor necrosis factor superfamily (ie. TNFSF7) and a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. CD70 is a single-pass type Ⅲ transmebrane glycoprotin consisting of a short cytoplasmic domain (1-17aa) , a transmembrane domain (18-38 aa) and a 155aa extracellular domain (39-193), and exists as a homotrimer in vivo. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 expression on malignant cells coupled with its highly restricted expression on normal cells makes CD70 an attractive target for monoclonal antibody -based therapies.

参考文献

Goodwin RG. et al., 1993, Cell. 73: 447-56.
Boursalian TE. et al., 2009, Adv Exp Med Biol. 647: 108-19.
Bowman MR. et al., 1994, J Immunol. 152: 1756-61.
McEarchern JA. et al., 2008, Clin Cancer Res. 14 (23): 7763-72.
Tesselaar K. et al., 2002, J Immunol. 169: 33-40.

规格：20ug

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