Rat THY1 Protein|技术资料|参数

THY1蛋白产品信息

别名: THY1, Thy-1
表达方式: 
A DNA sequence encoding the rat THY1 (P01830)(Met1-Lys129) was expressed with a polyhistidine tag at the C-terminus.
种属: Rat
表达宿主: Human Cells

THY1 Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gln 20
分子量: 
The recombinant rat THY1 comprises 121 amino acids and predicts a molecular mass of 14.1 kDa. The apparent molecular mass of  the recombinant protein is approximately 27-29 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

THY1 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

THY1蛋白背景综述

Thy-1 membrane glycoprotein, also known as Thy-1 antigen, CD90 and THY1, is a cell membrane protein which contains 1 Ig-like V-type (immunoglobulin-like) domain. THY1 / CD90, a member of the immunoglobulin superfamily of adhesion molecules with constitutive expression on fibroblast cells. THY1 / CD90 is a cell surface glycoprotein originally identified on mouse thymocytes. It has been identified on a variety of stem cells and at varying levels in non-lymphoid tissues such as on fibroblasts, brain cells, and activated endothelial cells. THY1 / CD90 is a membrane glycoprotein expressed in thymus, retinal ganglionic cells, and several types of stem cells. It was observed that THY1 / CD90 cell surface expression decreased significantly during the course of infection. In ***** rats, expression of THY1 / CD90 on the B cell lineage is confined to immature B cells. The expression of THY1 / CD90 on neonatal MZ-B cells may have implications for their responsiveness to polysaccharide (T cell-independent type 2) antigens. THY1 / CD90 is modulated following infection with Human cytomegalovirus (HCMV). Neuroblastoma (NBL) is the most common solid tumor in children. THY1 / CD90 seemed to be a marker with a specific prognostic value in NBL patients. THY1 / CD90 may also play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.

参考文献

Dammers PM. et al., 2002, Dev Immunol. 9 (4): 187-95.
Leis M. et al., 2004, J Gen Virol. 85 (7): 1995-2000.
Wiesmann A. et al., 2006, Head Face Med. 2: 8.
Fiegel HC. et al., 2008, Pediatr Surg Int. 24 (1): 101-5.
Kisselbach L. et al., 2009, Cytotechnology. 59 (1): 31-44.

规格：20ug

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