Rat SDC1 / Syndecan-1 / SYND1 Protein|厂家|价格

SDC1 / Syndecan-1 / SYND1蛋白产品信息

别名: SDC1, Synd1
表达方式: 
A DNA sequence encoding the rat SDC1 (P26260)(Met1-Lys253) was expressed with a polyhistidine tag at the C-terminus.
种属: Rat
表达宿主: Human Cells

SDC1 / Syndecan-1 / SYND1 Protein QC Testing

纯度: (76+20)% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gln 23
分子量: 
The recombinant rat SDC1 comprises 242 amino acids and predicts a molecular mass of 25.6 kDa. The apparent molecular mass of  the recombinant protein is approximately 47 and 49 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

SDC1 / Syndecan-1 / SYND1 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

SDC1 / Syndecan-1 / SYND1蛋白背景综述

Syndecan-1, also known as SYND1, CD138 and SDC1, is a single-pass type I  membrane protein which belongs to the syndecan proteoglycan family. CD138 / Syndecan-1 is well known to be associated with cell proliferation, adhesion, and migration in various types of malignancies. It is a cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. CD138 / Syndecan-1 is a cell-surface heparan sulfate proteoglycan expressed on most epithelial cells, and decreased CD138 expression is associated with increased invasive and metastatic potential in carcinomas. Within the hematopoietic system, CD138 is an excellent marker of plasmacytic differentiation. CD138 / Syndecan-1 is a cell surface proteoglycan that binds cells to the extracellular matrix and its expression is down-regulated in many cellular transformation models. CD138 / Syndecan-1 is a new simple non-invasive marker for predicting liver fibrosis in patients with chronic hepatitis C. The relevance of this marker in combination with other fibrosis markers should be explored. CD138 / Syndecan-1 might contribute to urothelial carcinoma cell survival and progression. It could be a new therapeutic target in urinary bladder cancer.

参考文献

O'Connell FP. et al., 2004, Am J Clin Pathol. 121 (2):254-63.
Gkden N. et al., 2006, Appl Immunohistochem Mol Morphol. 14 (2): 173-7.
Sun WP. et al., 2007, Cell Mol Immunol. 4 (3): 209-14.
Zvibel I. et al., 2009, Liver Int. 29 (2): 208-12.
Shimada K. et al., 2010, Cancer Sci. 101 (1): 155-60.

规格：50ug

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