Mouse BTLA Protein |技术资料|厂家

BTLA蛋白产品信息

别名: BTLA
表达方式: 
A DNA sequence encoding the mouse BTLA(Met1-Gly176) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Mouse
表达宿主: Human Cells

BTLA Protein QC Testing

纯度: > 90 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu 30
分子量: 
The recombinant mouse BTLA /Fc is a disulfide-linked homodimer. The reduced monomer comprises 388 amino acids and has a predicted molecular mass of 437 kDa. The apparent molecular mass of the protein is approximately 57-62 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

BTLA Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

BTLA蛋白背景综述

BTLA is a member of the immunoglobulin superfamily. It contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T(H)1) but not T(H)2 cells. BTLA is one of a growing number of inhibitory molecules that down-modulates immune responses. As such, reagents that regulate the binding of BTLA to its ligand or alter BTLA signaling have significant therapeutic promise. BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1). Polymorphisms in BTLA gene have been associated with an increased risk of rheumatoid arthritis.

参考文献

Fourcade J. et al., 2012, Cancer Res. 72 (4): 887-96.
Kojima R. et al., 2011, J Mol Biol. 413 (4): 762-72.
Oki M. et al., 2011, Clin Dev Immunol. 305656.

规格：50ug

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