Cynomolgus ALK-7 / ALK7 / ACVR1C Protein|厂家|价格

ALK-7 / ALK7 / ACVR1C蛋白产品信息

别名: ACVR1C
表达方式: 
A DNA sequence encoding the cynomolgus ACVR1C (F7GDQ6) (Leu44-Glu113) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Cynomolgus
表达宿主: Human Cells

ALK-7 / ALK7 / ACVR1C Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gly 25
分子量: 
The recombinant cynomolgus ACVR1C is a disulfide-linked homodimer. The reduced monomer comprises 330 amino acids and has a calculated molecular mass of 36.6 KDa.The apparent molecular mass of cynomolgus CD38  is approximately 42-46 KDa respectively in SDS-PAGE.
缓冲液: Lyophilized from sterile PBS, pH7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

ALK-7 / ALK7 / ACVR1C Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

ALK-7 / ALK7 / ACVR1C蛋白背景综述

ALK-7, also known as ALK7 and ACVR1C, is a member of the ALK family. ALK-7 is a serine-threonine kinase that can cause the activation of one of the SMAD signal transducers, SMAD2. It induces cell death by apoptosis through activation of the traditional TGF-beta pathway components in a process involving activation of SMAD2, SMAD3, caspase-3 and caspase-9. ALK-7 has a ligand known as Nodal. Nodal stimulates the secretion of TIMP-1 and inhibits matrix metalloproteinases MMP-2 and MMP-9 activity. The overexpression of Nodal or constitutively active ALK-7 decreases cell migration and invasion, whereas knock-down of Nodal and ALK-7 has the opposite effects.

参考文献

Lin YY. et al., 2012, Nature. 482 (7384): 251-5.
He C. et al., 2010, Hum Genet. 128 (5) :515-27.
Watanabe R. et al., 2008, Biochem Biophys Res Commun. 377 (3): 867-72.

规格：100iug

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