TNFRSF19 / TROY Protein |价格|产品详情

TNFRSF19 / TROY蛋白产品信息

别名: TNFRSF19, TAJ, TROY
表达方式: 
A DNA sequence encoding the human TNFRSF19 (Q9NS68-2) (Met1-Leu170) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Human
表达宿主: Human Cells

TNFRSF19 / TROY Protein QC Testing

纯度: > 85 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu 30
分子量: 
The recombinant human TNFRSF19/Fc is a disulfide-linked homodimer. The reduced monomer comprises 382 amino acids and has a predicted molecular mass of 42.5 kDa. The apparent molecular mass of the protein is approximately 52-57 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

TNFRSF19 / TROY Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

TNFRSF19 / TROY蛋白背景综述

Tumor necrosis factor receptor superfamily member 19, also known as, Toxicity and JNK inducer, TNFRSF19, TRADE and Troy, is a member of the TNF-receptor superfamily and contains 3 TNFR-Cys repeats. TNFRSF19 is highly expressed in ***** brain, and in embryos from day 11-17, but not earlier. It is detected in embryonic brain and epithelium, and at lower levels in ***** heart, lung and liver. In neonatal mice, TNFRSF19 is mainly expressed in hair follicles and neuron-like cells in the cerebellum, but not in the skin epidermis. TNFRSF19 has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. TNFRSF19 is the first TNFRSF member that is identified as a biomarker for melanoma. TNFRSF19 also presents a potentially novel cell surface signaling target for inhibitors, cell and/or antibody-based immunotherapies.

参考文献

Hu S. et al., 1999, Genomics. 62: 103-7.
Eby MT. et al., 2000, J Biol Chem. 275: 15336-42.
Kojima T. et al., 2000, J Biol Chem. 275: 20742-7.
Spanjaard RA. et al., 2007, Int J Cancer. 120 (6): 1304-10.

规格：20ug

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