APCS / PTX2 / Serum amyloid P component Protein|技术资料|厂家

APCS / PTX2 / Serum amyloid P component蛋白产品信息

别名: APCS, PTX2
表达方式: 
A DNA sequence encoding the human APCS (P02743) (Met1-Val223) was expressed with a polyhistidine tag at the C-terminus.
种属: Human
表达宿主: Human Cells

APCS / PTX2 / Serum amyloid P component Protein QC Testing

纯度: > 95% as determined by SDS-PAGE SDS-PAGE:

APCS / PTX2 / Serum amyloid P component protein
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: His 20
分子量: 
The recombinant human APCS consists of  215 amino acids and predicts a molecular mass of 24.7 KDa. It migrates as an approximately 31 KDa band in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

APCS / PTX2 / Serum amyloid P component Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Serum amyloid P component (SAP), also known as APCS AND Ptx2, is a 25kDa pentameric protein first identified as the pentagonal constituent of pathological deposits called "amyloid". SAP is a member of the pentraxins family, characterised by calcium dependent ligand binding and distinctive flattened β-jellyroll structure similar to that of the legume lectins. SAP has a marked inhibitory effect on the proliferative response of lymphocytes to a variety of T-dependent mitogens. In addition, SAP enhances the formation of active E rosettes, a marker of activated T cells. SAP has certain sequence homology with C-reactive protein (CRP), a classical acute phase response plasma protein, and both of which are evolutionary conserved in all vertebrates and also found in distant invertebrates.

参考文献

Cathcart, E. S. et al.,1967, Biochim. Biophy. Acta. 147: 392-3.
Levo,Y. et al., 1985, Int Arch Allergy Appl Immunol. 77 (3): 322-5.
Emsley, J. et al., 1994, Nature. 367 (6461): 338-45.
Pepys, M. B. et al.,1997,Amyloid-International Journal of Experimental and Clinical Investigation. 4: 274-95.

规格：50ug

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