CSF1R / M-CSFR / CD115蛋白产品信息
别名: CSF1R
表达方式:
A DNA sequence encoding the mouse CSF1R (Met1-Ser511) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
种属: Mouse
表达宿主: Human Cells
CSF1R / M-CSFR / CD115 Protein QC Testing
纯度: > 95% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Ala 20
分子量:
The recombinant mouse CSF1R/Fc is a disulfide-linked homodimer. The reduced monomer comprises 740 amino acids and has a predicted molecular mass of 83.3 kDa. The apparent molecular mass of the protein is approximately 110 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
CSF1R / M-CSFR / CD115 Protein Usage Guide
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
CSF1R / M-CSFR / CD115蛋白背景综述
M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1, a cytokine involved in the proliferation, differentiation, and activation of macrophages. As a member of the typeIII subfamily of receptor tyrosine kinases (RTKs), M-CSF receptor is expressed mainly on cells of monocyte/macrophage lineage, and consists of an extracellular ligand-binding domain and a cytoplasmic protein tyrosine kinase (PTK) domain joined through a single transmembrane helix. Ligand binding induces the M-CSF receptor homodimerization, and leads to transphosphorylation of specific tyrosine and the subsequent signal transduction. This activated receptor exerts actions on multiple intracellular effectors which determine the magnitude and specificity of the biological responses, and thus mediates most if not all of the biological effects of the CSF1 cytokine, including cell growth, survival, differentiation and chemotaxis. Mutations of this gene have been associated with a predisposition to myeloid malignancy.
参考文献
Sherr CJ. 1988, Biochim Biophys Acta. 948: 225-43.
Rohrschneider LR. et al., 1997, Mol Reprod Dev. 46: 96-103.
Hamilton JA. et al., 1997, J Luekoc Biol. 62: 145-55.
Roussel MF. et al., 1991, Nature. 353: 361-3.
Yeung Y. et al., 1998, J Biol Chem. 273.
Pixley FJ. et al., 2004, Trends Cell Biol. 14: 628-38.
Rovida E. et al., 2001, J Immunol. 166: 1583-9.
规格：50ug
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