Cynomolgus TNFRSF17 Protein|价格|产品详情

TNFRSF17蛋白产品信息

别名: TNFRSF17
表达方式: A DNA sequence encoding the cynomolgus TNFRSF17(F7FFA0) (Met1-Ala53) was expressed with the Fc region of human IgG1 at the C-terminus.
种属: Cynomolgus
表达宿主: Human Cells

TNFRSF17 Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Met
分子量: 
The recombinant cynomolgus TNFRSF17 is a disulfide-linked homodimer. The reduced monomer comprises 294 amino acids and has a calculated molecular mass of 33 KDa.The apparent molecular mass of the protein is approximately 38-42 KDa respectively in SDS-PAGE.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

TNFRSF17 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

TNFRSF17蛋白背景综述

The tumor necrosis factor (TNF) receptor superfamily are a group of cell surface receptors critically involved in the maintenance of homeostasis of the immune system. By interacting with their corresponding ligands, these receptors either induce cell death or promote cell survival of immune cells. Human tumor necrosis factor receptor superfamily member 17, also known as B-cell maturation protein, TNFRSF17, BCMA, and CD269, is a single-pass type I II membrane protein which contains one TNFR-Cys repeat. TNFRSF17 is a member of the TNF receptor superfamily, and is preferentially expressed in mature B lymphocytes. It binds specifically to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), as well as various TNFR-associated factor (TRAF) family members including TRAF1, TRAF2 and TRAF3 adaptor proteins, and thus transduces signals for cell survival and proliferation. Lacking a "death domain", overexpression of TNFRSF17 activates NF-kappa B and c-Jun N-terminal kinase. TNFRSF17 is also found in a perinulear Golgi-like structure.

参考文献

Hatzoglou A. et al., 2000, J Immunol. 165 (3): 1322-1330.
Zhou T. et al., 2002, Immunol Res. 26 (1-3): 323-336.
Liu Y. et al., 2003, Nature. 423: 49-56.
Hymowitz SG. et al., 2005, J Biol Chem. 280: 7218-7227.

规格：50ug

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