Cynomolgus IL17RA / IL17R Protein|厂家|现货

IL17RA / IL17R蛋白产品信息

别名: IL17RA
表达方式: 
A DNA sequence encoding the cynomolgus IL17RA (Met1-Trp320) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Cynomolgus
表达宿主: Human Cells

IL17RA / IL17R Protein QC Testing

纯度: > 90 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Leu 33
分子量: 
The recombinant cynomolgus IL17RA is a disulfide-linked homodimer. The reduced monomer comprises 529 amino acids and has a calculated molecular mass of 60.3 KDa.The apparent molecular mass of the protein is approximately 75-98 KDa respectively in SDS-PAGE.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

IL17RA / IL17R Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IL17RA / IL17R蛋白背景综述

Interleukin-17 receptor A, also known as IL-17 receptor A, IL-17RA, IL17RA and IL17R, is an ubiquitous type I  membrane glycoprotein that binds with low affinity to interleukin 17A (IL17A). IL17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. IL17A binds to a type I  cell surface receptor called IL17R of which there are at least three variants IL17RA, IL17RB, and IL17RC. IL17RA is a widely expressed glycoprotein that plays a central role in inflammatory responses. IL17R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. The aa sequence of mouse IL17RA is 69% identical to the human IL17R. Within the extracellular domain, mouse IL17RA shares 72% aa sequence identity with human IL17RA. IL17RA associates with IL17RC to form a signaling receptor complex for IL17 and IL17F. Ligand and IL17RA ligation promotes T cell activation and the production of IL-6, G-CSF, SCF, and multiple proinflammatory chemokines.

参考文献

Yao Z. et al., 1997. Cytokine. 9 (11): 794-800.
Schwander R. et al., 2000, J Exp Med. 191:1233-40.
Starnes T. et al., 2002, J Immunol. 169 (2): 642-6.
Toy D. et al., 2006, J Immunol. 177 (1): 36-9.
Takahashi N. et al., 2008, J Exp Med. 205 (8): 1755-61.
Smith E. et al., 2008, J Immunol. 181 (2): 1357-64.

规格：100ug

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