CLM-9 / TREM4 / CD300LG Protein|技术资料|价格

CLM-9 / TREM4 / CD300LG蛋白产品信息

别名: CD300LG, CLM9, TREM4
表达方式: 
A DNA sequence encoding the human CD300LG (AAH25395.1)(Met1-Arg247) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Human
表达宿主: Human Cells

CLM-9 / TREM4 / CD300LG Protein QC Testing

纯度: (74 +24.5) % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Leu 19
分子量: 
The recombinant human CD300LG/Fc is a disulfide-linked homodimer. The reduced monomer comprises 470 amino acids and has a predicted molecular mass of 51.7 kDa. The apparent molecular mass of the protein is approximately 70 and 34 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CLM-9 / TREM4 / CD300LG Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CLM-9 / TREM4 / CD300LG蛋白背景综述

CLM-9, also known as TREM4, is a member of the CD300 -like (CD300L) family. CLM-9 is widely expressed on hematopoietic cells. All CD300L proteins are type I cell surface glycoproteins that contain a single immunoglobulin (Ig) V-like domain.  It is a receptor which may mediate L-selectin-dependent lymphocyte rollings. CLM-9 binds SELL in a calcium dependent manner. CLM-9 also binds lymphocyte which suggests that it functions in lymphocyte adhesion. CLM-9 gene encodes the human and murine protein. The major CLM-9 transcript is expressed highly in human heart, skeletal muscle, and placenta. The mouse protein has been shown to be expressed in capillary endothelial cells. Human CLM-9 mediates the uptake of human IgA2 and mouse IgM.

参考文献

Clark GJ. et al., 2009, Immunobiology. 214 (9-10): 730-6.
Engel K. et al., 2012, J Inherit Metab Dis. 35 (1): 133-40.
Lamesch P. et al., 2007, Genomics. 89 (3): 307-15.

规格：20ug

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