GI24 / B7H5 Protein|技术资料|价格

C10orf54 / GI24蛋白产品信息

别名: Gi24, VISTA, B7H5, C10orf54
表达方式: 
A DNA sequence encoding the human Gi24 (AAH20568.1) (Met1-Ala194) was expressed with a polyhistidine tag at the C-terminus.
种属: Human
表达宿主: Human Cells

C10orf54 / GI24 Protein QC Testing

纯度: > 95% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Phe 33
分子量: 
The recombinant human Gi24 consists of  173 amino acids and predicts a molecular mass of 19.6 KDa. It migrates as an approximately 38-42 KDa band in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

C10orf54 / GI24 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

C10orf54 / GI24蛋白背景综述

C10orf54, also known as GI24, is a member of the immunoglobulin superfamily. As a transmembrane molecule, C10orf54 is expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. On ESCs, C10orf54 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state. On tumor cells, C10orf54 both promotes MT1-MMP expression and activity and serves as a substrate for MT1-MMP. This increases the potential for cell motility. Human C10orf54 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment.

参考文献

Ota T. et al., 2004, Nat Genet. 36 (1): 40-5.
Deloukas P. et al., 2004, Nature. 429 (6990): 375-81.
Colland F. et al., 2004, Genome Res. 14 (7): 1324-32.

规格：50ug

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