GIF / Gastric intrinsic factor Protein|技术资料|价格

GIF / Gastric intrinsic factor蛋白产品信息

别名: GIF, IFMH
表达方式: 
A DNA sequence encoding the human GIF (P27352-1) (Met1-Tyr417) was expressed with a polyhistidine tag at the C-terminus.
种属: Human
表达宿主: Human Cells

GIF / Gastric intrinsic factor Protein QC Testing

纯度: > 95% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Ser 19
分子量: 
The recombinant human GIF consists of  410 amino acids and predicts a molecular mass of 44.8 KDa. It migrates as an approximately 49 KDa band in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

GIF / Gastric intrinsic factor Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

GIF / Gastric intrinsic factor蛋白背景综述

Gastric intrinsic factor, also known as GIF, is a glycoprotein produced by the parietal cells of the stomach. It is a member of the cobalamin transport protein family. Gastric intrinsic factor is required for adequate absorption of vitamin B12 in the terminal ileum. Vitamin B12 is essential for erythrocyte maturation and mutations in the Intrinsic Factor may lead to congenital pernicious anemia. Vitamin B12 bounds to haptocorrin after entry into the stomach. The resulting complex enters the duodenum, where pancreatic enzymes digest haptocorrin. In the less acidic environment of the small intestine, B12 can then bind to gastric intrinsic factor. This new complex travels to the ileum, where special epithelial cells endocytose them. Inside the cell, B12 dissociates once again and binds to another protein, transcobalamin II. The new complex can exit the epithelial cells to enter the liver.

参考文献

Gerdin AK. 2010, Acta Opthalmologica. 88: 925-7.
AU - Berlin H. et al., 1968, Acta Medica Scandinavica. 184 (1-6): 247-58.
Hewitt JE. et al., 1991, Genomics. 10 (2): 432-40.

规格：20ug

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