Rat NCR1 Protein|技术资料|价格

NCR1蛋白产品信息

别名: NCR1, Ar1, Kilr1, Ly94
表达方式: 
A DNA sequence encoding the rat NCR1 (Q9Z0H5) (Met1-Asn255) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Rat
表达宿主: Human Cells

NCR1 Protein QC Testing

纯度: (73.6+23)%as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gln 17
分子量: 
The recombinant rat NCR1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 480 amino acids and has a predicted molecular mass of 54.1 kDa. The apparent molecular mass of the protein is approximately 65 and 36 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

NCR1 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

NCR1蛋白背景综述

NCR1, also known as NK-p46 and CD335, is called natural cytotoxicity receptors (NCR) together with NCR3 and NCR2. NKp46 has two extracellular Ig-like domains followed by a ~40 residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. It has been implicated in NK cell-mediated lysis of several autologous tumor cells, pathogen-infected cell lines and mononuclear phagocytes infected with an intracellular bacterium. NKp46 is a surface receptor involved in NK-cell cell death by apoptosis. NKp46 and its coreceptor CD59 together activate cytotoxicity of human NK-cells, their engagement results in tyrosine phosphorylation of CD3-zeta chains associated with NKp46.

参考文献

Carbone E. et al., 2005, Blood. 105 (1): 251-8.
Sivori S. et al., 1997, J Exp Med. 186 (7): 1129-36.
Biassoni R. et al., 2004, J Cell Mol Med. 7 (4): 376-87.

规格：50ug

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