TETHERIN / BST2 / CD317 Protein|价格|产品详情

TETHERIN / BST2 / CD317蛋白产品信息

别名: BST2
表达方式: 
A DNA sequence encoding the human BST2 (Q10589) (Asn49-Ser160) was expressed, with an N-terminal polyhistidine tag.
种属: Human
表达宿主: Human Cells

TETHERIN / BST2 / CD317 Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: His
分子量: 
The recombinant human BST2 comprises 132 amino acids and has a predicted molecular mass of 14.9 kDa. The apparent molecular mass of the protein is approximately 23-26 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

TETHERIN / BST2 / CD317 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Antibodies:
TETHERIN / BST2 / CD317蛋白背景综述

Tetherin also known as bone marrow stromal antigen 2 and BST2 is single-pass type Ⅱ membrane protein with an extracellular coiled coil domain forms a long semi-flexible rod-like structure important for virion retention at the cell surface and prevention of virus spreading. BST2 predominantly expressed in liver, lung, heart and placenta and low levels in pancreas, kidney, skeletal muscle and brain. This protein is found overexpressed in multiple myeloma cells. It is highly expressed during B-cell development, from pro-B precursors to plasma cells, and on T-cells, monocytes, NK cells and dendritic cells. BST2 is involved in the sorting of secreted proteins and in pre-B cell growth. As an antiretroviral defense protein, BST2 blocks release of enveloped virus from the cell surface. Active against at least four virus families: retroviruses, filoviruses, arenaviruses, and herpesviruses. BST2 is discovered as an inhibitor to HIV-1 infection in the absence of Vpu and it inhibits the release of other viruses such as the Lassa and Marburg virions.

参考文献

Ishikawa J. et al., 1995, Genomics. 26 (3): 527-34.
Viswanathan K. et al., 2011, PLoS Pathog. 7 (11): 10023-32.
Gifford RJ. 2011, Hum Mutat. 32 (11).

规格：20ug

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