Rat CEACAM1 / CD66a Protein|现货|厂家

CEACAM1 / CD66a蛋白产品信息

别名: CEACAM1
表达方式: 
A DNA sequence encoding the rat CEACAM1(Met1-Ser422) was expressed with a polyhistidine tag at the C-terminus.
种属: Rat
表达宿主: Human Cells

CEACAM1 / CD66a Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gln 35
分子量: 
The recombinant rat CEACAM1 comprises 399 amino acids and predicts a molecular mass of 44.9 kDa. The apparent molecular mass of  the recombinant protein is approximately 66-76 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CEACAM1 / CD66a Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CEACAM1 / CD66a蛋白背景综述

Carcinoembryonic antigen (CEA)-related cell adhesion molecule 1 (CEACAM1), also known as biliary glycoprotein I (BGP I) and CD66a, is a member of the carcinoembryonic antigen (CEA) gene family which belongs to the immunoglobulin superfamily. There are two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, and seven CEACAM has been identified in humans including type I  transmembrane proteins (CEACAM-1, CEACAM-3, CEACAM-4) and GPI-linked molecules (CEACAM-5, CEACAM-8). The highly glycosylated CEACAM1 contains one N-terminal V-type I g-like domain and three C2-type I g-like domains within its ECD, and one ITIM motif and a calmodulin binding site in the cytoplasmic region. It was described as an adhesion molecule mediating cell adhesion via both homophilic and heterophilic manners, and was detected on leukocytes, epithelia, and endothelia. Studies have revealed that CEACAM1 performs actions in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses.

参考文献

Hinoda Y. et al., 1988, Proc Natl Acad Sci. 85: 6959-63.
Zalzali H. et al., 2008, Oncogene. 27: 7131-8.
Erqun S. et al., 2000, Mol Cell. 5: 311-20.
Oliveira-Ferrer L. et al., 2004, Cancer Res. 64: 8932-8.

规格：50ug

关 键 词：Rat CEACAM1 / CD66a Protein,现货，实验室耗材，生化试剂，上海创赛，博飞美科，实验仪器，厂家

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