Rat KIRREL3 / NEPH2 Protein|技术资料|价格

KIRREL3 / NEPH2蛋白产品信息

别名: KIRREL3
表达方式: 
A DNA sequence encoding the rat KIRREL3(Q09GS6)(Met1-Ala523) was expressed with a polyhistidine tag at the C-terminus.
种属: Rat
表达宿主: Human Cells

KIRREL3 / NEPH2 Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Leu 22
分子量: 
The recombinant rat KIRREL3 comprises 513 amino acids and predicts a molecular mass of 56.4 kDa. The apparent molecular mass of  the recombinant protein is approximately 60-64 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

KIRREL3 / NEPH2 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

KIRREL3 / NEPH2蛋白背景综述

Kin of IRRE-like protein 3, also known as Kin of irregular chiasm-like protein 3, Nephrin-like protein 2 and KIRREL3, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily. KIRREL3 contains five Ig-like C2-type ( immunoglobulin-like ) domains. KIRREL3 is expressed in fetal and ***** brain. It is also expressed in kidney, specifically in podocytes of kidney glomeruli. KIRREL3 could be involved in the hematopoetic supportive capacity of stroma cells. KIRREL3 might play a role in the axonal pathfinding, cell recognition, and synapse formation of DRG neurons on appropriate target cells, including the targeting of proprioceptive neurons on muscle spindles through the interaction with nephrin. Defects in KIRREL3 are the cause of mental retardation autosomal dominant type 4 (MRD4) which is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental perio.

参考文献

Sellin L. et al., 2003, FASEB J. 17: 115-117.
Komori T. et al., 2008, J Comp Neurol. 511 (1): 92-108.
Bhalla K. et al., 2008, Am. J. Hum. Genet. 83: 703-713.

规格：50ug

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