Cynomolgus IGFBP4 Protein|价格|产品详情

IGFBP4蛋白产品信息

别名: IGFBP4
表达方式: 
A DNA sequence encoding the cynomolgus IGFBP4(Met1-Glu258 ) was expressed with a polyhistidine tag at the C-terminus.
种属: Cynomolgus
表达宿主: Human Cells

IGFBP4 Protein QC Testing

纯度: > 80 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Asp 22
分子量: 
The recombinant heterodimer of cynomolgus IGFBP4 comprises 248 amino acids and has a calculated molecular mass of 27.4 KDa. The apparent molecular mass of the protein is approximately 33-36 KDa respectively in SDS-PAGE.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

IGFBP4 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IGFBP4蛋白背景综述

Insulin-like growth factor-binding proteins (IGFBPs) control bioavailability, activity, and distribution of insulin-like growth factor (IGF) through high-affinity IGFBP/IGF complexes. Six high-affinity IGF-binding proteins (IGFBP-1 to -6) have been identified, and IGFBP4, the smallest IGFBP expressed by a wide range of cell types, exists in both non-glycosylated and N-glycosylated forms in all biological fluids. Structurally consisting of an IGFBP domain and a thyroglobulin type-I domain, IGFBP4 binds IGF-I and IGF-II with similar affinities as a transport protein and modulates their biological effects. Increasing evidences indicate that IGFBP4 inhibits IGF-induced cellular growth both in vitro and in vivo. As an important member of the IGF system, IGFBP4 is involved in a wide range of biological processes including reproductive physiology, bone formation, renal pathophysiology and carcinomas.

参考文献

Durai R. et al., 2006, Int J Oncol. 28: 1317-25.
Sitar T. et al., 2006, Proc Natl Acad Sci. 103: 13028-33.
Zhou R. et al., 2003, J Endocrinol. 178: 177-93.
Zhou J. et al., 2003, Biol Reprod. 69: 22-9.

规格：20ug

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