Rat Thrombomodulin / THBD Protein|技术资料|产品详情

Thrombomodulin / THBD蛋白产品信息

别名: THBD
表达方式: 
A DNA sequence encoding the rat THBD(O35370) (Met1-Ser517) was expressed with a polyhistidine tag at the C-terminus.
种属: Rat
表达宿主: Human Cells

Thrombomodulin / THBD Protein QC Testing

纯度: > 90 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Ile 17
分子量: 
The recombinant rat THBD comprises 512 amino acids and predicts a molecular mass of 55.2 kDa. The apparent molecular mass of  the recombinant protein is approximately 95 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

Thrombomodulin / THBD Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Thrombomodulin / THBD蛋白背景综述

Thrombomodulin, also known as THBD(CD141), is an integral membrane protein which expressed on the surface of endothelial cells and serves as a cofactor for thrombin. It is also expressed on human mesothelial cell, monocyte and a dendritic cell subset. Thrombomodulin reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. Thrombomodulin functions as a cofactor in the thrombin-induced activation of protein C in the anticoagulant pathway by forming a 1:1 stoichiometric complex with thrombin. Thrombomodulin also regulates C3b inactivation by factor I. Mutations in the thrombomodulin gene have also been reported to be associated with atypical hemolytic-uremic syndrome.

参考文献

Dzionek A. et al., 2002, Hum Immunol. 63 (12): 1133-48.
Dzionek A. et al., 2000, J Immunol. 165 (11): 6037-46.
Wen DZ. et al., 1987, Biochemistry. 26 (14): 4350-7.

规格：10ug

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