SMPDL3A Protein |技术资料|价格

SMPDL3A蛋白产品信息

别名: SMPDL3A, ASML3A
表达方式: 
A DNA sequence encoding the human SMPDL3A (Q92484) (Met1-Tyr453) was expressed with a polyhistidine tag at the C-terminus.
种属: Human
表达宿主: Human Cells

SMPDL3A Protein QC Testing

纯度: > 95% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Leu 23
分子量: 
The recombinant human SMPDL3A consists of  442 amino acids and predicts a molecular mass of 50.3 KDa. It migrates as an approximately 51 KDa band in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

SMPDL3A Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

SMPDL3A蛋白背景综述

Liver X receptors(LXRs) have been extensively studied in both human and rodent cell systems, revealing their potential therapeutic value in the contexts of atherosclerosis and inflammatory diseases. The LXR genome landscape has been investigated in murine macrophages but not in human THP-1 cells, which represent one of the frequently used monocyte/macrophage cell systems to study immune responses. LXRα and LXRβ function as physiological sensors of cholesterol metabolites (oxysterols), regulating key genes involved in cholesterol and lipid metabolism. SMPDL3A gene is a novel liver X receptor (LXR) -regulated gene, with an LXR response element within its promoter. The induction of SMPDL3A is LXR-dependent and is restricted to human blood cells with no induction observed in mouse cellular systems.

参考文献

Wright KO. et al., 2002, J Urol. 168 (6): 2645-9.
Strausberg RL. et al., 2002, Proc Natl Acad Sci. 99 (26): 16899-903.
Mungall AJ. et al., 2003, Nature. 425 (6960): 805-11.

规格：50ug

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