Rat TNFSF12 Protein|厂家|价格

TNFSF12蛋白产品信息

别名: TNFSF12, Prmt2
表达方式: A DNA sequence encoding the rat TNFSF12 (Arg105-His249) was expressed with Fc region of human IgG1 at the N-terminus.
种属: Rat
表达宿主: Human Cells

TNFSF12 Protein QC Testing

纯度: > 85 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu
分子量: 
The recombinant rat TNFSF12  comprises 405 amino acids and predicts a molecular mass of 44.4 kDa. The apparent molecular mass of  the recombinant protein is approximately 49 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

TNFSF12 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

TNFSF12蛋白背景综述

TNFSF12 is a member of the tumor necrosis factor (TNF) ligand family. Iit is a cytokine and also a ligand for the FN14/TWEAKR receptor. It binds to FN14 and possibly also to TNRFSF12/APO3. TNFSF12 has overlapping signaling functions with TNF, but displays a much wider tissue distribution. It can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. TNFSF12 is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. It also is a weak inducer of apoptosis in some cell types and mediates NF-kappa-B activation.

参考文献

Wiley SR. et al., 2004, Cytokine Growth Factor Rev. 14 (3-4): 241-9.
Campbell. S et al., 2006, Front Biosci. 9: 2273-84.
Lynch CN. et al., 1999, J Biol Chem. 274 (13): 8455-9.

规格：20ug

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