Rat LIFR Protein|鼠LIFR蛋白质|实验说明|现货

LIFR蛋白产品信息

别名: LIFR
表达方式: 
A DNA sequence encoding the rat LIFR(G3V7K2)(Met1-Ser829) was expressed with a polyhistidine tag at the C-terminus.
种属: Rat
表达宿主: Human Cells

LIFR Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Leu 44
分子量: 
The recombinant rat LIFR comprises 797 amino acids and predicts a molecular mass of 90 kDa. The apparent molecular mass of  the recombinant protein is approximately 116 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

LIFR Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

LIFR蛋白背景综述

Leukemia inhibitory factor receptor, also known as LIF receptor, CD118 and LIFR, is single-pass type I  membrane protein which belongs to the type I  cytokine receptor family and Type 2 subfamily. LIFR contains six fibronectin type-III domains. LIFR is a signal-transducing molecule. It may have a common pathway with IL6ST. LIFR is the receptor for leukemia inhibitory factor (LIF), a pleiotropic cytokine affecting the differentiation, survival, and proliferation of a wide variety of cells in the ***** and the embryo. The soluble form of LIFR inhibits the biological activity of LIF by blocking its binding to receptors on target cells. LIF action appears to be mediated through a high-affinity heterodimeric receptor complex consisting of two membrane glycoproteins: an α subunit that binds LIF with low affinity and the 130 kDa (gp130) subunit that does not bind LIF by itself, but is required for high-affinity binding of LIF by the complex. The gp130 subunit was first described as the signal transducing subunit of the high-affinity IL-6 receptor complex. Defects in LIFR are the cause of Stueve-Wiedemann syndrome (SWS), a severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias.

参考文献

Gearing DP. et al., 1991, EMBO J. 10 (10): 2839-48.
Gearing DP. et al., 1992, New Biol. 4 (1): 61-5.
Mosley B. et al., 1996, J. Biol. Chem. 271 (51): 32635-43.
Timmermann A. et al., 2002, Eur J Biochem. 269 (11): 2716-26.
Lass A. et al., 2002, Fertil Steril. 76 (6): 1091-6.

规格：50ug

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