Rat ADAM17 Protein |鼠ADAM17蛋白质|技术资料|现货

ADAM17蛋白产品信息

别名: ADAM17, Tace
表达方式: 
A DNA sequence encoding the rat ADAM17 (Q9Z1K9)(Met1-Asp563) was expressed with a polyhistidine tag at the C-terminus.
种属: Rat
表达宿主: Human Cells

ADAM17 Protein QC Testing

纯度: (73.2+23.7) % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Pro 18
分子量: 
The recombinant rat ADAM17 comprises 557 amino acids and predicts a molecular mass of 63 kDa. The apparent molecular mass of  the recombinant protein is approximately 57 and 20 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

ADAM17 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

ADAM17蛋白背景综述

ADAM17 is a member of the ADAM protein family of disintegrins and metalloproteases. ADAM17 is ubiquitously expressed in the human colon, with increased activity in the colonic mucosa of patients with ulcerative colitis, a main form of inflammatory bowel disease. The expression of ADAM17 may be inhibited by ethanol. It is involved in the processing of tumor necrosis factor alpha (TNF-α) at the surface of the cell, and from within the intracellular membranes of the trans-Golgi network. ADAM17 also plays a role in the release of a diverse variety of membrane-anchored cytokines, cell adhesion molecules, receptors, ligands, and enzymes. ADAM17 may play a prominent role in the Notch signaling pathway, during the proteolytic release of the Notch intracellular domain (from the Notch1 receptor) that occurs following ligand binding.

参考文献

Poghosyan. et al., 2002, J Biol Chem. 277 (7): 4999-5007.
Li Y. et al., 2006, Blood. 108 (7): 2275-9.
Peiretti. et al., 2003, J Cell Sci. 116 (10): 1949-57.

规格：10ug

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