Rat IL12B / IL-12B Protein|技术资料|价格

IL12B / IL-12B蛋白产品信息

别名: IL12B
表达方式: 
A DNA sequence encoding the rat IL12B (G3V9Y5)(Met1-Ser335) was expressed with a polyhistidine tag at the C-terminus.
种属: Rat
表达宿主: Human Cells

IL12B / IL-12B Protein QC Testing

纯度: (41.7+54.1) % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Met 23
分子量: 
The recombinant rat IL12B comprises 324 amino acids and predicts a molecular mass of 37.2 kDa. The apparent molecular mass of  the recombinant protein is approximately 47 and 45 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

IL12B / IL-12B Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IL12B / IL-12B蛋白背景综述

Interleukin 12 (IL-12), also known as NKSF or CLMF, is a disulfide-linked heterodimeric cytokine composed of a 35kDa subunit P35 and a 40kDa subunit P40, also designated as IL-12A and IL-12B. IL-12 is predominantly produced by macrophages and B lymphocytes and plays an important role in the activities of natural killer cells and T lymphocytes. It is involved in the differentiation and development of Th1 cells, enhancement of natural killer cells’ cytolytic function and mitogenic effects, as well as induction of IFN-gamma during which it can synergize with other IFN-gamma inducers. A large excess of monomeric IL-12B is also secreted by the cells producing IL-12, and exhibits no demonstrable biological activity. Overexpression of IL-12B has been shown to be associated with the pathogenesis of multiple sclerosis.

参考文献

Ling P. et al., 1995, J Immunol. 154: 116-27.
Thierfelder WE. et al., 1996, Nature. 382: 171-4.
Kato K. et al., 1996, Proc Natl Acad Sci. 93: 9085-89.
Kim JH. et al., 1997, Clin Exp Immunol. 108: 243-50.

规格：10ug

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