Rat ICOS / AILIM Protein |产品详情|价格

ICOS/ AILIM蛋白产品信息

别名: ICOS, Ailim
表达方式: 
A DNA sequence encoding the rat ICOS (Q9R1T7-1) (Met1-Leu142) was expressed with the Fc region of human IgG1 at the C-terminus.
种属: Rat
表达宿主: Human Cells

ICOS/ AILIM Protein QC Testing

纯度: > 95% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu 21
分子量: 
The recombinant rat ICOS /Fc is a disulfide-linked homodimer. The reduced monomer comprises 363 amino acids and has a predicted molecular mass of 40.7 kDa. The apparent molecular mass of the protein is approximately 43-47 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

ICOS/ AILIM Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

ICOS/ AILIM蛋白背景综述

Inducible costimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) is a cell-surface receptor, and belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. Optimal T cell activation and expansion are regulated by signals delivered not only through the T cell receptor (TCR), but also a number of costimulatory molecules. ICOS is expressed on antigen-primed T cells, and B7RP-1(or B7-H2) on B cells and macrophages has been identified as the ICOS ligand. The interaction of B7-H2/ICOS plays a critical role in Th cell differentiation, T-B cell interactions which is essential for germinal center formation, and humoral immune responses, and as well as the production of cytokine IL-4. In addition, ICOS also regulates TH2-mediated mucosal inflammatory responses partially through the signal for up-regulation of the chemokine receptors, and accordingly, aberrant expression of ICOS is implicated in allergic inflammatory responses and other immunity disorders.

参考文献

Hutloff A. et al., 1999, Nature. 397: 263-6.
Yoshinaga SK. et al. 1999, Nature. 402: 827-32.
Gonzalo JA. et al., 2001, Nat Immunol. 2: 597-604.
Coyle A.J. et al., 2000, Immunity. 13: 95-105.
Dong C. et al. 2001, Nature. 409: 97-101.
Aicher A. et al., 2000, J Immunol. 164: 4689-96.

规格：50ug

关 键 词：Rat ICOS / AILIM Protein,产品详情,价格，实验室耗材，生化试剂，上海创赛，博飞美科，实验仪器，厂家

CANSPEC品质提供的Rat ICOS / AILIM Protein |产品详情|价格性能**，其优良的品质满足您不同实验的多种需求。

本产品由上海创赛品质提供，欢迎咨询国内免费服务专线：400-608-7598，更多产品信息请登录www.canspecsci.com 或 www.4006087598.com