CD30 Ligand / TNFSF8蛋白产品信息
别名: TNFSF8
表达方式:
A DNA sequence encoding the cynomolgus TNFSF8(G7P2F1) (Gln63-Asp234) was expressed, with the Fc region of human IgG1 at the N-terminus.
种属: Cynomolgus
表达宿主: Human Cells
CD30 Ligand / TNFSF8 Protein QC Testing
纯度: > 90 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu
分子量:
The recombinant cynomolgus TNFSF8 is a disulfide-linked homodimer. The reduced monomer comprises 432 amino acids and has a calculated molecular mass of 48.1 KDa.The apparent molecular mass of the protein is approximately 59 KDa respectively in SDS-PAGE.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
CD30 Ligand / TNFSF8 Protein Usage Guide
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
CD30 Ligand / TNFSF8蛋白背景综述
CD30 ligand (CD30L), also known as CD153 and TNFSF8, is a cytokine belonging to the emerging tumor necrosis factor (TNF) ligand superfamily, and is a specific ligand for CD30/ TNFRSF8 originally described as a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. CD30L is a type-II membrane glycoprotein expressed on activated T cells, stimulated monocyte-macrophages, granulocytes, eosinophils, and some Burkitt-like lymphoma cell lines. CD30L is capable of transducing signals through CD30 on different CD30+ lymphoma cell lines, and mediates pleiotropic biologic effects including cell proliferation, activation, differentiation, as well as cell death by apoptosis. CD30-CD30 ligand interaction has been suggested to have a pathophysiologic role in malignant lymphomas, particularly Hodgkin disease, large cell anaplastic lymphomas and Burkitt lymphomas, and is also involved in activation and functioning of the T cell-dependent immune response.
参考文献
Gruss HJ. et al.,1994, Blood. 83: 2045-56.
Croager EJ. et al., 1997, Biochim Biophys Acta. 1353: 231-5.
Wendtner CM. et al., 1995, Cancer Res. 55: 4157-61.
Fischer M. et al., 2006, J Clin Invest. 116: 2748-56.
Blazar BR. et al., 2004, J Immunol. 173: 2933-41.
规格：50ug
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